On the advanced prostate cancer online support group there have been some questions raised about how we know when drugs like zytiga and xtandi have stopped working. When darolutamide starts to fail i can then move to a parp inhibitor and. He stopped zytiga because his psa went up and scans revealed many new spinal metastases, both indications that the zytiga was no longer effective. His psa was kept. First is change to xtandi.
Second is chemo with either taxtere or. Surgery was not an option. Zytiga stopped working after three years, and my husband has just begun treatment with pluvicto. It worked wonderfully well for those three years, and we knew it would. Instead, zytiga was considered to no longer be effective when three things happened: If your doctor thinks xtandi has stopped working they will advise you to stop taking it. In about 50 percent of the men whose psa level starts to rise again while on antiandrogen. My husband was on zytiga for approximately 7 months before it stopped working. When he started zytiga his psa continued to rise for about a month and then it started to drop.
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